Publikationen des Netzwerkes Epidermolysis bullosa

2008 / im Druck

• Dreier R, Opolka A, Grifka J, Bruckner P, Graessel S: Collagen IX-deficiency seriously compromises growth cartilage development in mice. Matrix Biol, in press
• Fritsch A, Loeckermann S, Kern JS, Braun A, Boesl MR, Bley T, Schumann H, von Elverfeldt D, Paul D, Erlacher M, Berens von Rautenfeld D, Hausser I, Faessler R, Bruckner-Tuderman L: A hypomorphic mouse model for dystrophic epidermolysis bullosa reveals disease mechanisms and responds to fibroblast therapy. J Clin Invest, in press.
• Huilaja L, Hurskainen T, Autio-Harmainen H, Hofmann SC, Sormunen R, Raesaenen J, Ilves M, Franzke CW, Bruckner-Tuderman L, Tasanen K: Pemphigoid gestationis autoantigen, transmembrane collagen XVII, promotes the migration of cytotrophoblastic cells of placenta and is a structural component of fetal membranes. Matrix Biol, in press [Epub ahead of print 2007]
• Moser M, Nieswandt B, Ussar S, Pozgajova M, Faessler R: Kindlin-3 is essential for integrin activation and platelet aggregation. Nat Med, in press.
• Uhlig P, Bruckner P, Dittrich R, Ringelstein EB, Nabavi DG, Kuhlenbaeumer G, Hansen U: Aberrations of dermal connective tissue in patients with cervical artery dissection (sCAD). J Neurol, in press.
• Wang H-V, Chang L-W, Brixius K, Wickstroem S, Montanez E, Thievessen I, Schwander M, Mueller U, Bloch W, Mayer U, Faessler R: Integrin-linked kinase stabilizes myotendinous junctions and protects muscle from stress-induced damage. J Cell Biol, in press.
• Zernikow B, Schumann H: Epidermolysis bullosa. In B. Zernikow (ed.), Palliativversorgung von Kindern, Jugendlichen und jungen Erwachsenen. Springer, in press
• Weitere Publikationen sind in Arbeit .

2007

• Arin MJ, Mueller FB: Keratins and their associated skin disorders. Eur J Dermatol 17:123-9, 2007.
• Arin MJ, Roop DR, Koch PJ, Koster MI: Biology of keratinocytes. In: Bologna, Rapini: Dermatology in Clinical Practice, 2007.
• Bouvard D, Aszodi A, Kostka G, Block MR, Albigès-Rizo C, Faessler R: ICAP-1 regulates osteoblast function in vivo. Development 134:2615-2625, 2007.
• Bruckner-Tuderman L, Has C: Hereditaere blasenbildende Hauterkrankungen. Kinder- und Jugendmedizin 5:257-263, 2007
• Dumitru RC, Buerkle T, Potapov S, Lausen B, Wiese B, Prokosch HU: Use and perception of internet for health related purposes in Germany: results of a national survey. Int J Public Health 52:275-85, 2007.
• Hartwig B, Borm B, Schneider H, Arin MJ, Kirfel G, Herzog V: Laminin-5-deficient human keratinocytes: defective adhesion results in a saltatory and inefficient mode of migration. Exp Cell Res 313:1575-1587, 2007.
• Hjorten R, Hansen U, Underwood RA, Telfer HE, Fernandes RJ, Krakow D, Sebald E, Wachsmann-Hogiu S, Bruckner P, Jacquet R, Landis WJ, Byers PH, Pace JM: Type XXVII collagen at the transition of cartilage to bone during skeletogenesis. Bone 41:535-542, 2007.
• Hoevelmeyer N, Wunderlich FT, Massoumi R, Jakobsen CG, Song J, Woerns MA, Merkwirth C, Kovalenko A, Aumailley M, Strand D, Bruening JC, Galle PR, Wallach D, Faessler R, Waisman A: Regulation of B cell homeostasis and activation by the tumor suppressor gene Cyld. J Exp Med 204:2615-2627, 2007.
• Kern J, Herz C, Haan E, Moore D, Nottelmann S, von Lilien T, Greiner P, Schmitt-Graeff A, Opitz O, Bruckner-Tuderman L, Has C: Chronic colitis due to an epithelial barrier defect: the role of kindlin-1 isoforms. J Pathol 22:462-470, 2007
• Klein A, Prokosch HU, Ganslandt T: Experiences with an Interoperable Data Acquisition Platform for Multi-Centric Research Networks Based on HL7 CDA. Methods Inf Med 46:580-5, 2007.
• Kohl K, Schnautz S. Pesch M, Klein E, Aumailley M, Bieber T, Koch S: Subpopulations of human dendritic cells display a distinct phenotype and bind differentially to proteins of the extracellular matrix. Eur J Cell Biol 86:719-730, 2007.
• Lorenz K, Grashoff C, Torka R, Sakai T, Langbein L, Bloch W, Aumailley M, Faessler R: ILK is required for epidermal and hair follicle morphogenesis. J Cell Biol 177:501-513, 2007.
• Lu H, Chen J, Zigrino P, Planko L, Klein-Hitpass L, Magin TM: Induction of inflammatory cytokines by a keratin mutation and their repression by small molecules in a mouse model for EBS. J Invest Dermatol 127:2781-2789, 2007.
• Magin TM, Vijayaraj P, Leube RL: Structural and regulatory functions of keratins. Exp Cell Res 313:2021-2032, 2007.
• Mansur AT, Elcioglu NH, Aydıngoez IE, Akkaya AD, Serdar ZA, Herz C, Bruckner-Tuderman L, Has C: Novel and recurrent KIND1 mutations in two patients with Kindler syndrome and severe mucosal involvement. Acta Derm Venereol 87:563-565, 2007.
• Nieswandt B, Moser M, Pleines I, Varga-Szabo D, Monkley S, Critchley D, Faessler R: Loss of talin1 in platelets abrogates integrin activation, platelet aggregation and thrombus formation in vitro and in vivo. J Exp Med, 204: 3113-3118, 2007.
• Opolka A, Ratzinger S, Schubert T, Spiegel H-U, Grifka J, Bruckner P, Probst A, Graessel S: Collagen IX is indispensable for timely maturation of cartilage during fracture repair in mice. Matrix Biol 26:85-95, 2007.
• Planko L, Boehse C, Hoehfeld J, Betz RC, Eigelshoven S, Hanneken S, Noethen MM, Kruse R, Magin TM: Identification of a keratin-associated protein with a putative role in vesicle transport. Eur J Cell Biol 86:827-839, 2007.
• Pourreyron C, Jones C, Mao X, Cox G, Volz A, Baksh N, Wong T, Fassihi H, Arita K, O’Toole EA, Chen M, Hart IR, Bruckner-Tuderman L, Salas-Alanis JC, McGrath JA, Leigh IM, South AP: Patients with recessive dystrophic epidermolysis bullosa develop squamous cell carcinoma regardless of type VII collagen expression. J Invest Dermatol 127:2438-44, 2007
• Ruehland C, Schoenherr E, Robenek H, Hansen U, Iozzo RV, Bruckner P, Seidler DG: The glycosaminoglycan chain of decorin plays an important role in collagen fibril formation at the early stages of fibrillogenesis. FEBS Journal 274:4246-4255, 2007.
• Volz A, Has C, Schumann H, Bruckner-Tuderman L: Network epidermolysis bullosa: molecular pathomechanisms and novel therapeutic approaches. J Dtsch Dermatol Ges 5:274-9, 2007.
• Zigrino P, Steiger J, Fox JW, Loeffek S, Schild A, Nichst R, Mauch C: Role of ADAM-9 disintegrin-cysteine-rich domains in human keratinocyte migration. J Biol Chem 282:30785-93, 2007.
• Zimina EP, Fritsch A, Schermer B, Bakulina AY, Bashkurov M, Benzing T, Bruckner-Tuderman L: Extracellular phosphorylation of collagen XVII by ecto-casein kinase 2 inhibits ectodomain shedding. J Biol Chem 282:22737-46, 2007.

2006

• Allen JM, Bateman, JF, Hansen U, Wilson, R, Bruckner P, Owens RT, Sasaki T, Timpl R, Fitzgerald J: WARP is a novel multimeric component of the chondrocyte pericellular matrix that interacts with perlecan. J Biol Chem 281:7341-7349, 2006.
• Aumailley M, Has C, Tunggal L, Bruckner-Tuderman L: Molecular basis of inherited skin blistering disorders, and therapeutic implications. Expert Rev Mol Med 8:1-21, 2006
• Betz RC, Planko L, Eigelshoven S, Hanneken S, Pasternack S, Buessow H, van den Bogaert K, Braun-Falco M, Ruetten A, Rogers MA, Ruzicka T, Noethen MM, Magin TM, Kruse R: Loss-of-Function Mutations in the Keratin 5 Gene Lead to Dowling-Degos Disease. Am J Hum Genet 78:510-519 2006.
• Birkmann C, Dumitru RC, Prokosch HU: Evaluation of health-related Internet use in Germany. Methods Inf Med 45(4):367-76, 2006.
• Broekaert SM, Knauss-Scherwitz E, Biedermann T, Metzler G, Has C, Kohlhase J, Rocken M, Schaller M: Epidermolysis bullosa pruriginosa due to a glycine substitution mutation in the COL7A1-gene. Acta Derm Venereol 86:556-557, 2006.
• Bruckner P: Supramolecular structure of cartilage matrix. In: Seibel MJ, Robins SP, Bilezekian JP, editors. Dynamics of bone and cartilage metabolism, 2nd edition. San Diego, CA: Academic Press 407-420, 2006.
• Chometon G, Zhang ZG, Rubinstein E, Boucheix C, Mauch C, Aumailley M: Dissociation of the complex between CD151 and laminin-binding integrins permits migration of epithelial cells. Exp Cell Res 312:983-995, 2006.
• Czuchra A, Meyer H, Legate K, Brakebusch C, Faessler R: Genetic analysis of β1 integrin ‘activation motifs’ in mice. J Cell Biol 174:889-899, 2006.
• Franzke C-W, Has C, Schulte C, Huilaja L, Tasanen K, Aumailley M, Bruckner-Tuderman L: C-terminal truncation impairs glycosylation of transmembrane collagen XVII and leads to intracellular accumulation. J Biol Chem 281:30260-30268, 2006.
• Hansen U, Hussain M, Villone D, Herrmann M, Robenek H, Peters G, Sinha B, Bruckner P: The anchorless adhesin Eap (extracellular adherence protein) from Staphylococcus aureus selectively recognizes extracellular matrix aggregates but binds promiscuously to monomeric matrix macromolecules. Matrix Biol 25:252-260, 2006.
• Has C, Bruckner-Tuderman L: Molecular and diagnostic aspects of genetic skin fragility, J Dermatol Sci 44:129-144, 2006.
• Has C, Chang Y, Volz A, Hoeping D, Kohlhase J, Bruckner-Tuderman L: Novel keratin 14 mutations in patients with severe recessive epidermolysis bullosa simplex. J Invest Dermatol 126:1912-1914, 2006.
• Has C, Wessagovit V, Pascucci M, Baer C, Biagio D, Wilhelm C, Pedicelli C, Locatelli A, Kohlhase J, Ashton G, Tadini G, Zambruno G, Bruckner-Tuderman L, McGrath J, Castiglia D: Molecular basis of Kindler syndrome in Italy: novel and recurrent Alu/Alu recombination, splice site, nonsense, and frameshift mutations in the KIND1 gene. J Invest Dermatol 126, 1776 - 1783, 2006.
• Herz C, Aumailley M, Schulte C, Schloetzer-Schrehardt U, Bruckner-Tuderman L, Has C: Kindlin-1 is a phosphoprotein involved in regulation of polarity, proliferation and motility of epidermal keratinocytes. J Biol Chem 281:36082-36090, 2006.
• Kern J, Kohlhase J, Bruckner-Tuderman L, Has C: Expanding the COL7A1 mutation database: novel and recurrent mutations and unusual genotype - phenotype constellations in 41 patients with dystrophic epidermolysis bullosa. J Invest Dermatol 126:1006-10012, 2006.
• Loeffek S, Zigrino P, Steiger J, Kurschat P, Smola H and Mauch C: Melanoma cell-derived vascular endothelial growth factor induces endothelial tubulogenesis within fibrin gels by a metalloproteinase-mediated mechanism. Eur J Cell Biol 85:1167-77, 2006.
• Loranger A, Gilbert S, Brouard J-S, Magin TM, Marceau N: Keratin 8 modulation of desmoplakin deposition at desmosomes in hepatocytes. Exp Cell Res 312:4108-4119, 2006.
• Lu H, Zimek A, Chen J, Hesse M, Buessow H, Weber K, Magin TM: Keratin 5 knockout mice reveal plasticity of keratin expression in the corneal epithelium. Eur J Cell Biol 85:803-811, 2006.
• Magin TM, Reichelt J, Chen J: The role of keratins in epithelial homeostasis. In Skin Barrier (ed. Peter M. Elias & Kenneth R. Feingold). New York: Taylor & Francis, 141-170, 2006.
• Massoumi R, Chmielarska K, Hennecke K, Pfeifer A, and Faessler R: Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling. Cell 125:665-677, 2006.
• Mueller FB, Kuester W, Wodecki K, Almeida Jr. H, Bruckner-Tuderman L, Krieg T, Korge BP and Arin MJ: Novel and recurrent mutations in keratin KRT5 and KRT14 genes in epidermolysis bullosa simplex: Implications for disease phenotype and keratin filament assembly. Hum Mutat 27:719-720, 2006.
• Parikka M, Nissinen L, Kainulainen T, Bruckner-Tuderman L, Salo T, Heino J, Tasanen K: Collagen XVII promotes integrin-mediated squamous cell carcinoma transmigration - a novel role for aIIb integrin and tirofiban. Exp Cell Res 312:1431-1438, 2006.
• Poblete-Gutierrez P, Burgdorf WH, Has C, Berneburg M, Frank J: [Hereditary photodermatoses.] Hautarzt 57:1067-82, 2006.
• Schietke R, Broehl D, Wedig T, Herrmann H, Magin TM: Mutations in vimentin disrupt the cytoskeleton in fibroblasts and delay execution of apoptosis. Eur J Cell Biol 85:1-10, 2006.
• Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltheis L, Omary MB, Parry DAD, Rogers MA, Wright M: The new nomenclature for mammalian keratins. J Cell Biol 174:169-174, 2006.
• Strnad P, Lienau TC, Tao G-Z, Ku N-O, Magin TM, Omary MB: Denaturing temperature selection may underestimate keratin mutation detection by DHPLC. Hum Mutat 27:444-452, 2006.
• Veit G, Hansen, U, Keene, DR, Bruckner P, Chiquet-Ehrismann R, Chiquet M, Koch M: Collagen XII interacts with avian tenascin-X through its NC3 domain. J Biol Chem 281:27461-27470, 2006.
• Vijayaraj P, Soehl G, Magin TM: Keratin transgenic and knockout mice. In: Target Discovery and Validation, Vol. 1, edited by M Sioud. Humana Press, 203-251, 2006.
• Zinn M, Aumailley M, Krieg T, Smola H: Expression of laminin 5 by parental and c-Ha-ras-transformed HaCaT keratinocytes in organotypic cultures. Eur J Cell Biol 85:333-343, 2006.

2005

• Aumailley M, Bruckner-Tuderman L, Carter WG, Deutzmann R, Edgar D, Ekblom P, Engel J, Engvall E, Hohenester E, Jones JC, Kleinman HK, Marinkovich MP, Martin GR, Mayer U, Meneguzzi G, Miner JH, Miyazaki K, Patarroyo M, Paulsson M, Quaranta V, Sanes JR, Sasaki T, Sekiguchi K, Sorokin LM, Talts JF, Tryggvason K, Uitto J, Virtanen I, von der Mark K, Wewer UM, Yamada Y, Yurchenco PD: A simplified laminin nomenclature. Matrix Biol 24:326-32, 2005.
• Birk DE, Bruckner P: Collagen suprastructures. Top Curr Chem 247:185-205, 2005.
• Budde B, Blumbach K, Ylostalo J, Zaucke F, Ehlen HWA, Wagener R, Ala-Kokko L, Paulsson M, Bruckner P, Graessel S: Altered integration of matrilin-3 into cartilage extracellular matrix in the absence of collagen IX. Mol Cell Biol 25:10465-10478, 2005.
• Csikos M, Szocs M, Laszik A, Mecklenbeck S, Horvath A, Karpati S, Bruckner-Tuderman L: High frequency of the 425A-->G splice-site mutation and novel mutations of COL7A1 gene in Central-Europe: significance for future mutation-detection strategies in dystrophic epidermolysis bullosa. Br J Derm 152:879-886, 2005.
• Dai L, Alt W, Schilling K, Gieselmann V, Magin TM, Kappler J: A fast and robust quantitative time-lapse assay for cell motility. Exp Cell Res 311:272-280, 2005.
• Franzke C-W, Bruckner P, Bruckner-Tuderman L: Collagenous transmembrane proteins: recent insights into biology and pathology. J Biol Chem 280:4005-4008, 2005.
• Klein A, Ganslandt T, Prokosch HU, Brinkmann L, Ueckert F: An XML-based remote data entry solution in a multi-centric research network. J Qual Life Res 3(2):190-197, 2005.
• Li S, Bordoy R, Stanchi F, Moser M, Braun A, Kudlacek O, Wewer UM, Yurchenco PD, Faessler R: PINCH1 regulates cell-matrix and cell-cell adhesions, cell polarity and cell survival during the peri-implantation stage. J Cell Sci 118: 2913-2921, 2005.
• Loeffek S, Zigrino P, Angel P, Anwald B, Krieg T, Mauch C: High invasive melanoma cells induce matrix metalloproteinase-1 synthesis in fibroblasts by interleukin-1alpha and basic fibroblast growth factor-mediated mechanisms. J Invest Dermatol 124, 638-643, 2005.
• Lu H, Hesse M, Peters B, Magin TM: Type II keratins precede type I keratins during early mouse development. Eur J Cell Biol 84:709-718, 2005.
• Moali C, Font B, Ruggiero F, Eichenberger D, Rousselle P, Francois V, Oldberg A, Bruckner-Tuderman L, Hulmes DJ: Substrate-specific modulation of a multisubstrate proteinase. C-terminal processing of fibrillar procollagens is the only BMP-1-dependent activity to be enhanced by PCPE-1. J Biol Chem 280:24188-24194, 2005.
• Mueller FB, Kuester W, Wodecki K, Almeida Jr H, Bruckner-Tuderman L, Krieg T, Korge BP, Arin MJ: Novel and recurrent mutations in keratin KRT5 and KRT14 genes in Epidermolysis bullosa simplex: Implications for disease phenotype and keratin filament assembly. J Invest Dermatol 125: A26, 2005
• Stefanova M, Zemke K, Dimitrov B, Has C, Kern J, Bruckner-Tuderman L, Kutsche K: Disruption of ERBB2IP is not associated with dystrophic epidermolysis bullosa in both father and son carrying a balanced 5;13 translocation. J Invest Dermatol 125:700-704, 2005.

2004

• Fontao L, Tasanen K, Huber M, Hohl D, Koster J, Bruckner-Tuderman L, Sonnenberg A, Borradori L: Molecular consequences of delition of the cytoplasmic domain of bullous pemphigoid BP180 in a patient with predominant features of epidermolysis bullosa simplex. J Invest Dermatol 122:65– 72, 2004.
• Ganslandt T, Ruderich F, Prokosch HU: Building a Communications Infrastructure for a Multi-Centric Research Network. J Qual Life Res 2(1):125-127, 2004.
• Has C, Bruckner-Tuderman L: A novel nonsense mutation in Kindler syndrome. J Invest Dermatol 122:84-86, 2004.
• Has C, Kern J, Bruckner-Tuderman L: Hereditaere blasenbildende Hauterkrankungen. Hautarzt 55: 920-930, 2004.
• Herzog C, Has C, Franzke CW, Echtermeyer FG, Schlotzer-Schrehardt U, Kroger S, Gustafsson E, Fassler R, Bruckner-Tuderman L: Dystroglycan in skin and cutaneous cells: beta-subunit is shed from the cell surface. J Invest Dermatol 122(6):1372-1380, 2004.
• Kassner A, Tiedemann K, Notbohm H, Ludwig T, Moergelin M, Reinhardt DP, Chu M-L, Bruckner P, Graessel, S: Molecular structure and interaction of recombinant human type XVI collagen. J Mol Biol 339:835-853, 2004.
• Koch M, Schulze J, Hansen U, Ashwodt T, Keene DR, Brunken WJ, Burgeson RE, Bruckner P, Bruckner-Tuderman L: A novel marker of tissue junctions, collagen XXII. J Biol Chem 279:22514-22521, 2004.
• Krampert M, Bloch W, Sasaki T, Bugnon P, Rulicke T, Wolf E, Aumailley M, Parks WC, Werner S: Activities of the matrix metalloproteinase stromelysin-2 (MMP-10) in matrix degradation and keratinocyte organization in wounded skin. Mol Biol Cell 15:5242-5254, 2004.
• Magin TM, Reichelt J, Hatzfeld M: Familiar structure, emerging functions: Diseases and animal models reshape our view of the cytoskeleton. Exp Cell Res 301:91-102, 2004.
• Marneros AG, Hansen U, Keene DR, Fukai N, Moiseyev G, Goletz PL, Halfter W, Sucai D, Pawlyk BS, Shibata M, Li T, Crouch, RK, Bruckner P, Olsen BR: Collagen XVIII/endostatin is essential for vision and retinal pigment epithelial function. EMBO J 23:89-99, 2004.
• Reichelt J, Fuerstenberger G, Magin TM: Loss of keratin 10 leads to MAP kinase activation, increased keratinocyte turnover and decreased tumor formation in mice. J Invest Dermatol 123:973-981, 2004.
• Reichelt J, Magin TM, Sandhoff K, Breiden B: Loss of keratin 10 is accompanied by altered sebocyte proliferation and differentiation. Eur J Cell Biol 83:747-759, 2004.
• Schara U, Tuecke J, Mortier W, Nuesslein Th, Rouan F, Pfendner E, Zillikens D, Bruckner-Tuderman L, Uitto J, Wiche G, Schroeder R: Severe mucous membrane involvment in epidermolysis bullosa simplex with muscular dystrophy due to a novel plectin gene mutation. Eur J Paediatr 163:218-222, 2004.
• Tasanen K, Tunggal L, Chometon G, Bruckner-Tuderman L, Aumailley M: Keratinocytes from patients lacking collagen XVII display a migratory phenotype. Am J Pathol 164:2027-2038, 2004.
• Werner NS, Windoffer R, Strnad P, Grund C, Leube RE, Magin TM: Epidermolysis Bullosa Simplex-type mutations alter the dynamics of the keratin cytoskeleton and reveal a contribution of actin to the transport of keratin subunits. Mol Biol Cell 15:990-1002, 2004.

2003

• Baldeschi C, Gache Y, Rattenholl A, Bouillé P, Danos O, Ortonne J-P, Bruckner-Tuderman L, Meneguzzi G: Genetic correction of canine dystrophic epidermolysis bullosa mediated by retroviral vectors. Hum Mol Genet 12:1897-1905, 2003.
• Hambrock HO, Nitsche, DP, Hansen, U, Bruckner P, Paulsson, M, Maurer, P, Hartmann, U: SC1/hevin. An extracellular calcium-modulated protein that binds collagen I. J Biol Chem 278:11351-11358, 2003.
• Hansen U, Bruckner P: Macromolecular specificity of collagen fibrillogenesis: Fibrils of collagens I and XI contain a heterotypic alloyed core and a collagen I sheath. J Biol Chem 278:37352-37359, 2003.
• Herrmann H, Reichenzeller M, Hesse M, Aebi U, Magin TM: Functional Complexity of Intermediate Filament Cytoskeletons: From Structure to Assembly to Gene Ablation. Int Rev Cytol 223:83-175, 2003.
• Kassner A, Hansen U, Miosge N, Reinhardt DP, Aigner T, Bruckner-Tuderman L, Bruckner P, Graessel, S: Supramolecular association of collagen XVI to different fibrillar systems in human skin and cartilage. Matrix Biol 22:131-143, 2003.
• Kirfel J, Magin TM, Reichelt J: Keratins: A structural scaffold with emerging functions. Cell Mol Life Sci 60:56-71, 2003.
• Magin TM: A keeper and a striker maintain epidermal homeostasis. Nat Genet 35:202-204, 2003.