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 Pathogenesis and classification  

Dermo-epidermal junction zone

Schematic representation of the dermo-epidermal junction zone (DEJZ)

  • The dermo-epidermal junction zone (DEJZ) connects the epidermis and dermis.
  • It is composed of a network of structural proteins, which provides a firm connection between the basal keratinocytes and the dermis.
  • This structural network is made up of:
  1. hemidesmosome-anchoring filament complex
  2. basement membrane with two layers, the lamina lucida and the lamina densa
  3. anchoring fibrils.
  • The basal keratinocytes are connected to the basement membrane via the hemidesmosome-anchoring filament complex, which in turn is connected to the dermis via anchoring fibrils.